Surprisingly, CPT1B has been shown to be associated with mechanisms of drug resistance in multiple cancers such as bladder cancer, prostate cancer, etc. (Iwamoto et al., 2018; Wang et al., 2018; Vantaku et al., 2019; Abudurexiti et al., 2020) However, there are still no relevant studies on the relationship between CPT1B and drug resistance in ccRCC. The gene discussed is CPT1B; the disease is nonpapillary renal cell carcinoma.