WNK2 and amyotrophic lateral sclerosis: It is well known that, more than 25% of human protein kinases belong to serine/threonine protein kinases and are involved in regulating numerous signaling transduction cascades (Rask-Andersen et al., 2014), including the Mitogen-activated protein kinase (MAPK) family, Akt kinase (protein kinase B), Mammalian target of rapamycin (mTOR), and so on, which are reported to be strongly linked with the development of ALS (Halon-Golabek et al., 2019; Sama et al., 2017; Saxena et al., 2013).