Notably, although these genes have not been demonstrated to be directly associated with ALS in previous studies, NR4A1 (Zhao et al., 2018) and DRD4 (Lin et al., 2012) are reported in AD, ACSL4 seems to be a biomarker of ferroptosis (Yuan et al., 2016), and SETD1B is associated with syndromic neurodevelopmental disorder (Weerts et al., 2021). The gene discussed is NR4A1; the disease is neurodevelopmental disorder.