CHMP5 has not been reported in previous ALS related research, and SLC38A1 is a main transporter of glutamine and has been reported as a positive regulator of mTOR complex 1 (mTORC1), which is closely connected with autophagy and plays an essential role in many neurodegenerative diseases (Lipton and Sahin, 2014; Yamada et al., 2019). Here, CHMP5 is linked to amyotrophic lateral sclerosis.