EDA is a unique gene involved in the pathogenesis of X-linked hypohidrotic ectodermal dysplasia (XLHED; OMIM 305100), which accounts for 95% of patients with HED, and the remaining 5% are mainly due to autosomal dominant or recessive inheritance (Clarke et al., 1987; Clauss et al., 2008; Deshmukh and Prashanth, 2012; Wang et al., 2020). Here, EDA is linked to X-linked hypohidrotic ectodermal dysplasia.