Genetic variations in ectodysplasin A (EDA) pathway genes, such as EDA, ectodysplasin A receptor (EDAR), and EDAR-associated adapter protein (EDARADD) are known to be associated with hypohidrotic ED (HED); the prevalence of which is ∼1/100,000 (Khabour et al., 2010; Deshmukh and Prashanth, 2012; Okita et al., 2019). This evidence concerns the gene EDA and hypohidrotic ectodermal dysplasia.