Moreover, high TOP2A mRNA expression was also significantly associated with poor overall survival and diseases free survival of patients with adrenocortical carcinoma, breast invasive carcinoma, kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, brain lower grade glioma, liver hepatocellular carcinoma, lung adenocarcinoma, mesothelioma, or pancreatic adenocarcinoma. The gene discussed is TOP2A; the disease is pancreatic adenocarcinoma.