In the current study, a comprehensive pan-cancer analysis of TOP2A among 33 solid tumors was performed based on the public databases of TCGA and GEO, including the multiple factors of the gene/total protein expressions, the survival prognostic value, the genetic alteration, the protein mutation, the protein phosphorylation, the immune cell infiltration and the related signaling pathways of TOP2A. Here, TOP2A is linked to cancer.