TOP2A and neoplasm: The KEGG pathway and GO enrichment analyses were then performed using the online bioinformatics tool “HIPLOT,” which showed that the “Wnt signaling pathway” might be the most important signaling pathway involved in TOP2A trigged tumor pathogenesis (Figure 7B); and the GO enrichment analysis data further indicated that most of these genes were linked to DNA structure, biological complex, and protein kinase activity, such as DNA conformation change, PcG protein complex, protein serine/threonine kinase activity (Figure 7C).