Emerging studies have been indicated that the TRIM family not only contributed to the progression of HCC but also participated in the modulation of HBV infection (Fan et al., 2019; Liu et al., 2020; Mu et al., 2020), while to date, the relationship of TRIM with HBV-associated hepatocarcinogenesis is not well investigated. This evidence concerns the gene TRAT1 and hepatocellular carcinoma.