OLFML2B may activate a number of cancer-associated pathways, such as PI3K-Akt signaling pathway, focal adhesion, ECM–receptor interaction, proteoglycans in cancer, and leukocyte transendothelial migration, which indicates that OLFML2B may promote tumorigenesis, migration, and regulate tumor immune response. The gene discussed is MMRN1; the disease is neoplasm.