For example, it was found that when human hepatoma HepG2 cells became infected with HBV, there was an enhanced expression of LDL receptors, to promote cellular uptake of cholesterol, and HMG-CoA reductase, to promote the cellular synthesis of cholesterol [23], which indicates that HBV has a marked need for cholesterol [23]. This evidence concerns the gene LDLR and hepatocellular carcinoma.