Thus, in one study elevated CRP patients with schizophrenia displayed significantly worse working memory and CRP was inversely correlated with cortical thickness in frontal, insula, and temporal brain regions (45), while in another study increased CRP level was mildly associated with worse performance in attention and with reduced cortical thickness in the caudal middle frontal, the pars opercularis and the posterior cingulate cortices—three regions related to attention (46). This evidence concerns the gene CRP and schizophrenia.