PDK1 and infection: Notably, HIF-1α is important for neutrophil survival in normoxia as well as hypoxia, and VEGFA and many other HIF-1α target genes, but not HIF1A itself, are upregulated following LVS infection including HK2, LDHA, PDK1 and SCL2A1 (Cramer et al., 2003; Schwartz et al., 2013).