COL5A1 and infection: At early moments of infection, T. cruzi is known to interact with components of ECM inducing matrix remodeling and some of the genes associated to “EM transition” (Hallmark) and “ECM organization” (Reactome) are part of the proposed T. cruzi-ECM interactome (MMP2/COL1A2/COL6A2/COL5A1) regulated by the parasite molecule gp38 (Nde et al., 2012).