(De Filippo et al., 2013) found that under the stimulation of LPS, mast cells also released neutrophil chemokines, CXCL1 and CXCL2, through the TLR4-mediated MyD88 pathway, and in mast cell-deficient mice, LPS stimulation of the mouse peritoneum resulted in greatly reduced neutrophil recruitment to the site of infection. This evidence concerns the gene TLR4 and infection.