Previous studies collectively suggested that a lower CD4/CD8 ratio during cART is associated with a persistently higher HIV DNA (Gandhi et al., 2017), AIDS- or non-AIDS-related events and deaths (Mussini et al., 2015; Caby et al., 2021), and frailty of older HIV-infected adults (Branas et al., 2017). This evidence concerns the gene CD4 and AIDS.