However, only a lower CD4/CD8 ratio could predict inferior OS (HR = 2.103, 95% CI = 1.156–3.827, P = 0.015) and PFS (HR = 1.853, 95% CI = 1.030–3.334, P = 0.040) independently in the multivariate analysis, adjusted for the lymphoma- and HIV-associated parameters (Tables 2, 3). This evidence concerns the gene CD8A and lymphoma.