Strikingly, we found that cells from active TB patients expressed the lowest levels of IFIT1, IFIT2, and IFIT3 mRNA, whereas healthy controls had at least double the transcript level as compared to active TB patients, and LTBI participants had even higher expression levels (4-fold to 8-fold higher than active TB) [Figures 1 (D–F)]. This evidence concerns the gene IFIT3 and tuberculosis.