APOA1 and obesity due to melanocortin 4 receptor deficiency: A study associating SNPs in the ApoA1 gene and obesity with the risk of low HDL-C disease showed that participants with the rs670 G allele had a 1.46 times (OR) greater risk of low HDL-C disease compared with other alleles (95% CI: 1.118–1.915; p=0.005) [33].