BCL2 and endometrial cancer: Studies have shown that shikonin can inhibit the proliferation and induce apoptosis of endometrial cancer Ishikawa cells (Yang et al., 2013) and human ovarian cancer SKOV-3 cells (Wang et al., 2016a) in vitro, and the mechanism may be related to up-regulation of Bax expression and down-regulation of Bcl-2 expression.