In the CNS, SRC-1 is localized in specific regions and regulated by steroidal and non-steroidal factors; loss-of-function and gain-of–function studies have revealed it is profoundly involved in the regulation of hippocampus-dependent spatial memory, reproductive behaviors and neuropsychiatric disorders, brain tumor pathology and even required for normal motor function.10 Here, SRC is linked to brain neoplasm.