Since obesity in DicerCKO mice is associated with the loss of the Dicer1 gene both in AgRP and POMC neurons (10), while miR-15-5p is highly expressed in POMCCre-GFP neurons (Figure S2), we sought to genetically inactivate this microRNA in POMCCre-Cas9-GFP cells during adulthood (Figure 3A). The gene discussed is AGRP; the disease is obesity due to melanocortin 4 receptor deficiency.