Furthermore, long-term exposure to high-fat diet increases Bace1 expression in the brain promoting β-amyloid (Aβ) accumulation and cognitive deficits (37), while treatment with Bace1 inhibitor reduces circulating levels of Aβ1-42 peptide (38) in high-fat diet-induced obese mice. This evidence concerns the gene BACE1 and Cognitive impairment.