Taken together, CT imaging big data-assisted arterial chemoembolization combined with 125I seed implantation for NSCLC can reduce lesion blood perfusion, lesion volume, and serum CEA and CA125 levels and increase serum miR-137 and miR-379-5p levels to inhibit cancer progression, thereby improving short-term efficacy and long-term prognosis of NSCLC patients. This evidence concerns the gene CEACAM5 and cancer.