Matsui et al. it have shown that higher serum levels of PlGF are independent predictors of all-cause mortality and cardiovascular events in patients with CKD, with greater strength than traditional risk factors (69); Specifically, patients with plasma PlGF levels of 19.6 pg/mL showed an 8.42-fold increase in cardiovascular mortality and a 3.87-fold increase in all-cause mortality when compared to patients with lower PlGF levels (10.1 pg/mL) (69). This evidence concerns the gene PGF and chronic kidney disease.