Consistently, VEGF or PDGF-C induced JAM-C translocating from cytoplasm to the cytomembrane to maintain the normal function of the human iBRB, while increased serum sJAM-C was identified as a potential marker of wet age-related macular degeneration (wAMD) (150). The gene discussed is JAM3; the disease is age-related macular degeneration.