By examining the literature for known associations related to heart diseases, for example, whether the gene variants have been reported in patients with congenital heart diseases, whether mutant mice showed abnormal cardiac development, or whether they were involved in biological processes associated with cardiac development, we finally identified a heterozygous missense variant in exon 25 of MYOM2 gene, c.3097C>T (p.R1033C) as a possible genetic cause of TOF. Here, MYOM2 is linked to congenital heart disease.