APOB and Hypercholesterolemia: Besides, the mutations of some genes like LDLR, apolipoprotein B, and proprotein convertase subtilisin/kexin type 9 (PCSK9), can result in hypercholesterolemia, and guidelines suggested that non-HDL-C ≥ 220 mg/dl could possibly imply hereditary genetic hypercholesterolemia (11, 24).