It was found in our research that the high arterial stiffness group (baPWV ≥ 1,400 cm/s) had a higher plasma concentration of fibulin-1 than those with normal arterial stiffness (baPWV < 1,400 cm/s) after adjusting for blood pressure, FBG, blood lipid, Type 2 diabetes, and hyperlipidemia. This evidence concerns the gene FBLN1 and type 2 diabetes mellitus.