This protocol proposes a methodology for carrying out a systematic review and meta-analysis that is aimed at (1) focusing on the efficacy and safety role of EGFR-TKIs combined with RT for BMs from NSCLC and (2) displaying the difference in efficacy of EGFR-TKIs owing to the sites of BMs, the numbers of BMs, different types of RT, EGFR mutation status, and the subtypes of EGFR mutations by subgroup analysis. This evidence concerns the gene EGFR and non-small cell lung carcinoma.