Shmelkov et al. have discovered the protein amounts of glutamate receptor subunits NAMDAR2A, NAMDAR2B, Glutamate Receptor-1, and Glutamate Receptor-2 involved in excitatory neurotransmission were decreased by 20–60% in SliTrk5 deficiency mice, greatly modulating the glutamatergic neurotransmission of specific region [16].The sequence variation of SliTrk5 was also considered may be associated with the structural neuroimaging phenotype of obsessive-compulsive disorder [76]. The gene discussed is SLITRK5; the disease is obsessive-compulsive disorder.