BDNF and central nervous system cancer: Some studies have shown that the activation of TRKB-BDNF signal pathway can promote nerve cells to synthesize and secrete vascular endothelial growth factor(VEGF), thus promoting the growth of tumor cells [83, 84].Therefore, some researchers have speculated that SliTrk5 may stimulate the occurrence and proliferation of glioma by modulating TRKB-BDNF signal pathway and other related signal transduction.