The coaction targets were mainly enriched in several diseases and some pathways: pathways in cancer, hepatitis B, lipid and atherosclerosis, proteoglycans in cancer, Salmonella infection, PI3K-Akt signaling pathway, fluid shear stress, atherosclerosis, chemical carcinogenesis-receptor activation, oxytocin signaling pathway, VEGF signaling pathway, Th17 cell differentiation, and natural killer cell-mediated cytotoxicity. The gene discussed is AKT1; the disease is atherosclerosis.