In SK-BR-3 cells, the GTN-induced apoptosis was associated with autophagy via p-p38 and p-JNK1/2 upregulation and Akt downregulation [25], whereas nonapoptotic cell death mechanisms, namely, necroptosis and anoikis, induced by GTN were reported in human invasive breast cancer cells MDA-MB-231 [26]. Here, MAPK8 is linked to invasive breast carcinoma.