It was found that the intestinal mucosal barrier was destroyed in the IgAN rat model, and the drug use to protect the intestinal mucosa could reduce the pathological damage associated with IgAN to rat kidney tissue: IgA deposition in mesangial area, 24-h urine protein, and microscopic hematuria were found to be decreased (30). The gene discussed is CD79A; the disease is Microscopic hematuria.