In a study of the relationship between MBD and NP, Mo et al. (67) demonstrated that MBD1 deficiency in the DRG triggered a reduction in pain hypersensitivity following peripheral nerve injury; MBD1 recruits DNMT3a to the promoters of the Oprm1 and Kcna2 genes in DRG neurons, inhibiting MOR and Kv1.2 expression and inducing NP. The gene discussed is OPRM1; the disease is peripheral nerve injury.