In a study of the relationship between MBD and NP, Mo et al. (67) demonstrated that MBD1 deficiency in the DRG triggered a reduction in pain hypersensitivity following peripheral nerve injury; MBD1 recruits DNMT3a to the promoters of the Oprm1 and Kcna2 genes in DRG neurons, inhibiting MOR and Kv1.2 expression and inducing NP. This evidence concerns the gene KCNA2 and peripheral nerve injury.