Additionally, Wang et al. observed that CTSB released from lysosomes promoted severe acute pancreatitis by activating NLRP3 inflammasome which induced self-cleavage of caspase-1 and its maturation into an activated form; this in turn promoted the maturation and secretion of various proinflammatory cytokines including IL-1β and IL-18, triggering caspase-1-induced pyroptosis (3). The gene discussed is IL18; the disease is acute pancreatitis.