Notably, serum anti-HBc levels with a cutoff value of 4.00 log10 IU/mL to indicate liver inflammation had a higher specificity in HBeAg-positive patients (78.85%) than in HBeAg-negative patients (62.16%), suggesting that serum anti-HBc level can better mirror hepatic inflammation in HBeAg-positive patients than in HBeAg-negative patients. The gene discussed is KRT88P; the disease is inflammation.