Similarly, the Sirt1‐mediated brain‐protective effect of Maresin1 (macrophage mediator in resolving inflammation) in a mouse model subjected to middle cerebral artery occlusion demonstrates the involvement of Sirt1 signalling in the reduction of mitochondrial damage in the context of cerebral ischemia reperfusion injury.32 Here, SIRT1 is linked to Cerebral ischemia.