TP53 and Encephalopathy: Our current study elucidates the mechanism underlying the NR‐mediated improvement of encephalopathy in Ndufs4KO mice, that is, deacetylation of p53 to inactivate the p53‐dependent apoptotic pathway and restoration of neuronal GSH, leading to attenuation of neuronal apoptosis and the reduction of microglial activation in the cerebellum and the brainstem region.