As shown in Table 2, univariate logistic regression analyses identified ECOG PS score ≥ 2 (Odds ratio [OR], 14.9; 95% CI, 5.1–43.3; p < 0.001), liver metastasis (OR, 7.6; 95% CI, 2.4–23.4; p < 0.001), tumor size ≥ 5 cm (OR, 2.6; 95% CI, 1.03–6.6; p = 0.04), neutrophils ≥ 69% (OR, 3.5; 95% CI, 1.3–9.7; p = 0.01), lymphocytes < 22% (OR, 10.1; 95% CI, 2.3–45.3; p = 0.002), sNLR ≥ 4 (OR, 4.2; 95% CI, 1.6–11; p = 0.004), CRP ≥ 1 mg/dl (OR, 6.6; 95% CI, 1.9–23.4; p = 0.003), and Alb < 3.58 g/dl (OR, 3.5; 95% CI, 1.5–7.7; p = 0.002) as significant risk factors for early death during ICI monotherapy. This evidence concerns the gene ALB and neoplasm.