TARDBP and amyotrophic lateral sclerosis: Indeed, a spectrum of insoluble TDP‐43 species has been described correlating with pathological subtype and even disease severity [30]: frontotemporal lobar degeneration or FTLD type TDP‐C [31] is associated with very dense TDP‐43 aggregates as compared to TDP‐43 extracted from FTLD‐TDP‐A or ALS.