Positive for VIM, HMB45, and TFE3; negative for CK, CD34, S‐100, SMA, and desmin; the p53 gene mutations were about 90%; the Ki‐67 score was about 90%; a small number of tumor cells forming a cribriform or glandular tubular shape were described with moderate atypia, positive for CK7 and TTF‐1; negative for CK5/6 and P40; the Ki‐67 score was about 15%. The gene discussed is DES; the disease is neoplasm.