Although the increase in plasma HOXD‐AS1 and RMRP levels in patients with NSCLC demonstrated statistically significant differences when compared with healthy controls (p = 0.038 and p = 0.032, respectively; Figure 2C,D), the degree of increase was inferior to that of CEA and CYFRA21‐1 (p = 0.012 and p = 0.02, respectively; Figure 2E,F). This evidence concerns the gene CEACAM5 and non-small cell lung carcinoma.