To explore whether TP73‐AS1 and CRNDE possess differential diagnostic capacities for different histological subtypes of NSCLC, we performed pairwise group comparisons of the two lncRNAs in three subgroups of all cases, consisting of training and testing sets, lung adenocarcinoma (LAD), lung squamous cell carcinoma (LSCC), and health controls. This evidence concerns the gene TP73 and non-small cell lung carcinoma.