Since it is specified that increased glutamate and cytokines are involved in stimulating NKCC1 activity following cerebral ischemia[22], it seems that the effect of miRNA-149-5p and CoQ10 on inflammatory pathways and subsequently reduction of the inflammatory factors and oxidative stress decreases phosphorylation and expression of NKCC1, thereby reducing the risk of cerebral ischemia, including neuronal damage. Here, SLC12A2 is linked to brain ischemia.