In vitro studies have demonstrated an anti-oncogenic and an anti-metastatic effect of tinzaparin which have been attributed to (a) the TFPI, and its property of inhibiting both procoagulant and non-coagulant effects of TF [81], (b) its interference in the angiogenesis process which was shown to be dose-related and dependent on the relatively higher molecular weight tinzaparin fragments, and (c) its ability to prevent chemo-resistance in certain cancer types [81–84]. This evidence concerns the gene TF and cancer.