More specifically, TNF-induced RIPK1 signaling can trigger Caspase-8-dependent apoptosis [11], or in the absence of Caspase-8 activity can associate with RIPK3 and MLKL to cause necroptosis [12–15]–a lytic form of cell death implicated in the pathogenesis of numerous inflammatory disorders including Crohn’s disease and ulcerative colitis [16–19]. This evidence concerns the gene CASP8 and Crohn disease.