The red-meat diet induces an increase in Bacteroidales and Clostridiales to produce Neu5Gc, which is a potential factor contributing to the inflammation-mediated promotion of diseases and carcinomas.268 In active human Crohn disease, ω−3 and ω−6 PUFAs induce chemokine expression in epithelial cells by activating toll-like receptor 2 (TLR2)/inositol-requiring enzyme 1α (IRE1α) in epithelial cells.269 Some nutrition strategies are enabled to sustain intestinal homoeostasis. The gene discussed is TLR2; the disease is Crohn disease.