Mechanistically, FMD decreases the ratio of Tregs to immunosuppressive myeloid cells in peripheral areas and strengthens intratumoral cytotoxic effectors to profoundly remodel antitumor immunity.344 Considering the nutrient proportions, a low-protein diet reduces tumour growth through expansion of antigen-presenting cells (APCs) and CD8+ T cells.345 Unexpectedly, abnormal accumulation of potassium ions (K+) in the tumour interstitial fluid has been found to contribute to impaired T-cell effector function through suppression of AKT-mTOR signalling.346. The gene discussed is CD8A; the disease is neoplasm.