Additionally, we also demonstrated that circPABPC1 recruits KDM4C to the HMGA2 promoter, reduces its H3K9me3 modification and initiates transcription in the nucleus, and we also showed that cytoplasmic circPABPC1 promotes CRC progression by protecting ADAM19 and BMP4 from miR-874-/miR-1292-mediated degradation. This evidence concerns the gene HMGA2 and colorectal carcinoma.