IGFBP3 and neoplasm: Conversely, overexpression of SALIS significantly promoted tumor growth and formed bigger xenograft tumors (Supplementary Fig. S5a–c) and decreased IGFBP3 and Caspase-7 expression (Supplementary Fig. S5d, e) together with the reduction of BAX and generation of cleaved Caspase-3 and Caspase-7 (Supplementary Fig. S5d).