GO terms for downregulated genes common to BC and CB KO clones (≥ 1.25 TPM fold change) are enriched in cardiac ventricle development (e.g. Foxh1 and Adamts6), consistent with heart malformations observed in utero in Kdm6a KO mice (Fig. 1E) [21, 43]. The gene discussed is FOXH1; the disease is breast cancer.