Interestingly, the GO terms bone development (e.g. Has2) and hard palate development (e.g. Cbfb) are also highlighted, consistent with high-arched palate and other distinctive bone and facial features observed in Kabuki type 2 syndrome caused by KDM6A mutations in human (Fig. 1D, E) [45–48]. Here, CBFB is linked to Kabuki syndrome 2.