MAML2 gene rearrangement was the most frequent molecular alteration encountered in MEC, seen in 1337/2009 (66.6%) of cases (Table 3 and Fig. 3), followed by mutations in ERBB2 (9/126, 7.1%), KRAS (11/266, 4.1%), and EGFR (11/329 cases, 3.3%). The gene discussed is EGFR; the disease is mucoepidermoid carcinoma.