In order to prove the function of TRPC3 expressed on the MT-CAFs in the tumor microenvironment, we detected the expression of the pro-inflammatory factors IL6 and IL8 in MT-CAFs, and the results showed that IL6 and IL8 expression was obviously decreased after knocking down TRPC3 derived from MT-CAFs (Fig. 4A). The gene discussed is CXCL8; the disease is neoplasm.