C1S and depressive symptom measurement: In female participants, 3 significant association were observed, including CNTN2 vs. depression score in brain (Bonferroni-adjusted P value threshold: 7.14 × 10− 4, r = 0.01, P = 6.43 × 10− 4), C1-Esterase Inhibitor vs. neuroticism score in CSF (r = -0.01, P = 1.83 × 10− 5) and plasma (r = -0.01, P = 5.73 × 10− 7) (Fig. 2).