Considering the anti-oxidant [21], insulin-sensitizing actions [24], hypoglycemic properties [25], and pro-lipolytic effects of Taurine [19], our study aimed to evaluate the impact of Taurine supplementation along with calorie restriction on endothelial, oxidative stress, and inflammation markers, as well as glycemic control in patients with T2DM. This evidence concerns the gene INS and type 2 diabetes mellitus.