Although HAND2 are found to act crucial roles in development, mainly focusing on regulating downstream targets as one transcription factor [12, 13, 19], only one recent study reveals epigenetic silencing roles of HAND2 in early carcinogenesis of endometrial cancer [8], it remains unclear whether HAND2 methylation has functional relevance in other types of cancers. The gene discussed is HAND2; the disease is cancer.