In the tumor-types subgroup analysis, patients with positive lymphatic metastasis in the CRC (OR = 4.53, 95% CI: 2.36–8.70, p = < 0.00001), GC (OR = 3.52, 95% CI: 1.97–6.30, p < 0.0001) and ESCC (OR = 4.13, 95% CI: 2.68–6.35, p < 0.00001) groups presented a correlation with high CSN5 expression. Here, COPS5 is linked to colorectal carcinoma.