There are recommendations for Residual Kidney function preservation as Avoidance of nephrotoxic agents, especially aminoglycosides, NSAIDs, CoX-2 (Cyclooxygenase-2) inhibitors and radiocontrast media, Avoidance of excessive ultrafiltration, routine use of biocompatible dialyzer membranes, routine use of bicarbonate- based dialysate, use of ultrapure water, hemodiafiltration, incremental hemodialysis, and a low-protein diet, as well as general care such as maintaining appropriate blood pressure, and better control of mineral and bone disorder parameters [27, 28]. This evidence concerns the gene PTGS2 and bone disorder.